SYNERGY: of DIOXINS

What are the combined effects of the dioxin family?

Unless it can be shown otherwise we must assume that dioxins, furans, PCBs and others will add together to give a total dioxin-like toxicity. 

This has been shown experimentally for dioxins and furans (Eadon, 1986), but doubts have been expressed about the validity of adding the PCBs' contribution in the same way (Goldstein & Safe, 1989). Studies have been carried out that show PCBs acting against and reducing TCDD effects. 

However, a moderately toxic PCB, which produced only mild pre-birth effects in mice on its own, was found to increase TCDD effects in those mice tenfold (Birnbaum et al., 1985).

In addition: 

PCBs are a mixture of dioxin-like and non-dioxin-like molecules. Some bind strongly to the Ah receptor and others only weakly. 

PCBs have been reported to exert other effects separately from their action through the Ah receptor: for example there are effects on nerve signal transmission linked to a PCB which binds only weakly to the Ah receptor (Seegal et al., 1990).

Certain PCBs can increase the levels of the Ah receptor in the liver, and hence increase susceptibility to low doses of other dioxin-like compounds(Goldstein & Safe, 1989). 

However, laboratory investigations of interactions such as these cannot possibly cover all that are possible in humans and animals exposed in the environment to the whole range of dioxin-like compounds. 

Considering both the evidence for enhancement and lessening of effects, we have to assume that the different compounds add together to produce a total dioxin-like toxicity, which can be estimated by using the TEFs given earlier. 

In other words, dioxins plus PCBs equals more dioxins.

ORIGINAL SOURCE

Dioxin! The Facts

Dioxin! 
What Citizens, Workers and Policymakers Should Know.





Linda Birnbaum, who is currently the director of the National Institute of Environmental Health Sciences discusses what dioxin is, how toxic it is, and whether it causes cancer.

Although the interview was conducted in 2004 when Dr. Birnbaum  was head of the EPA  Division of Toxicology, we believe it continues to provide a useful and easy to understand summary of some of the available evidence against dioxin.

The video was originally commissioned in 2004 by the Ecology Center of Ann Arbor and the Public Interest Research Group In Michigan, but has never been released publicly until today. Thanks to the Ecology Center and Dr. Birnbaum for agreeing to make this public.

Let Us Spray

After viewing via internet
“Let Us Spray”
The confronting and awful reality of what has happened in New Plymouth in regards to dioxin poisoning is indelibly clear.

My name is Gary Green and on several occasions I appear in this documentary as a sufferer from dioxin poisoning caused from airborne exposure whilst working in close proximity to a herbicide manufacturing plant for 2,4-D and 2,4,5-T, when we lived in New Plymouth, New Zealand.

As I watched this documentary my heart was torn and on several occasions quite tearful as I viewed the traumatic struggles and medical impacts of others affected by Dioxin exposure.

The clarity that we all have experienced; continual denial to recognition and recompense and medical assistance as sufferers of dioxin poisoning was undeniable

To give you insight of what a sufferer must endure I have chosen to point out I am personally in the process of claiming ACC the claim was lodged 19th October 2005 and received an outcome of that claim 12th July 2006 “claim for cover is declined “, we have engaged a Barrister to pursue a fair and just settlement in the high courts for our appeal against the denial of ACC. Our appeal was a 3000 page plus document addressing every point ACC. used to deny us a rightful claim. "2014" The claim is now in appeal at the High Courts of New Zealand awaiting a determination

I would ask the people of New Zealand to unit with us and become a single coherent voice which plainly shows the will of the people concerning this issue.

As part of my efforts personally to lift the awareness of what has happened in New Plymouth I set up a website to provide a single web portal for the people of New Zealand to have access to which provides all the information which has been scattered in multiple websites worldwide.

The name of our site is www.dioxinnz.com

I would truly appreciate your assistance in bringing the awareness of this site to the people of New Zealand.

We Invite You to Financially Support the Efforts : Donate Here

That entire effort of Dioxinnz.com has been possible by actual sufferers of dioxin poisoning who are on pensions giving towards costs to exist.

We would ask for the people of New Zealand to rally around us in our campaign to get recognition and a fair and just settlement; and medical treatment

Your donations will enable us to continue the campaign and keep the website dioxinnz.com online.

And will also enable us to increase intensity of bringing the current incumbent Government to a place where they accept the realities of what has happened and begin to take care of those whom have become victims of industrial misadventure.

EDITED 22/02/2014